MLS8969 

MLS8969 is a selective human cytomegalovirus (HCMV) entry inhibitor with an EC₅₀ of 0.12 μM (HFFs). MLS8969 reduces viral protein levels and inhibits nuclear staining of HCMV pp65. MLS8969 can be used in studies related to human cytomegalovirus infection^[1][2].

MLS8969 potently inhibits HCMV strains in human foreskin fibroblasts (HFFs), with an EC₅₀ of 0.12 μM^[1].
MLS8969 exhibits multiplicity of infection (MOI)-dependent inhibition of pp28-luciferase reporter activity in human foreskin fibroblasts (HFFs) infected with human cytomegalovirus (HCMV), with strong inhibition at low MOI and extremely weak inhibition at an MOI of 1 PFU/cell^[1].
MLS8969 reduces the protein levels of HCMV IE1/2, pp65, UL84 and UL44 in human foreskin fibroblasts (HFFs) when administered prior to infection at a multiplicity of infection (MOI) of 0.01 PFU/cell; however, it does not inhibit viral protein expression at an MOI of 1 PFU/cell^[1].
MLS8969 inhibits human cytomegalovirus (HCMV) entry into human foreskin fibroblasts (HFFs)^[1].
MLS8969 acts synergistically with Ganciclovir (HY-13637) and letermovir to inhibit the replication of human cytomegalovirus (HCMV) in human foreskin fibroblasts (HFFs)^[1].
MLS8969 (0.16-2.5 µM; 72 h) inhibits CMV replication in human foreskin fibroblasts, with an EC₅₀ of 0.25 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

370.79

C₁₉H₁₅ClN₂O₄

347337-33-1

O=C(NC1=CC=C(C=C1)NC(=O)C2=CC(Cl)=CC=C2OC)C=3OC=CC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kapoor A, et al. Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus. J Med Chem. 2020;63(8):3896-3907.  [Content Brief]

  [2]. Guo X, et al. The Synthesis and Anti-Cytomegalovirus Activity of Piperidine-4-Carboxamides. Viruses. 2022;14(2):234. Published 2022 Jan 25.