1. Anti-infection
  2. Influenza Virus
  3. Nucleozin

Nucleozin 

Cat. No.: HY-50001 Purity: 99.74%
Handling Instructions

Nucleozin, a potent inhibitor of influenza A virus infection, induces the formation of nucleoprotein (NP) aggregates and antagonizes its nuclear accumulation, leading to cessation of viral replication. Nucleozin impedes influenza A virus replication in vitro with a nanomolar EC50.

For research use only. We do not sell to patients.

Nucleozin Chemical Structure

Nucleozin Chemical Structure

CAS No. : 341001-38-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 74 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 74 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 67 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
25 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 384 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Nucleozin purchased from MCE. Usage Cited in: Antiviral Res. 2017 Jul;143:106-112.

    MDCK cells are infected with H1N1/09pdm at an MOI of 10 in the presence of DMSO, CAE (60 μM) or Nucleozin (1 μM). At 3 h later, cells are fixed by 4% paraformaldehyde and NP is detected by IFA. Nuclei are stained with DAPI. Immunofluorescence is observed with a Nikon A1 confocal microscope.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Nucleozin, a potent inhibitor of influenza A virus infection, induces the formation of nucleoprotein (NP) aggregates and antagonizes its nuclear accumulation, leading to cessation of viral replication. Nucleozin impedes influenza A virus replication in vitro with a nanomolar EC50[1].

    In Vitro

    Nucleozin inhibits infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 and Vietnam/1194/04 (H5N1) with an EC50 of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assay (PRA) , respectively, severely suppresses viral growth at 0.1 μM and totally inhibites virus production at 1 μM in multicycle growth assays[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Nucleozin protectes mice challenged with lethal doses of avian influenza A H5N1[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    426.85

    Formula

    C₂₁H₁₉ClN₄O₄

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (46.85 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3427 mL 11.7137 mL 23.4274 mL
    5 mM 0.4685 mL 2.3427 mL 4.6855 mL
    10 mM 0.2343 mL 1.1714 mL 2.3427 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2 mg/mL (4.69 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2 mg/mL (4.69 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.74%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Nucleozin
    Cat. No.:
    HY-50001
    Quantity:
    MCE Japan Authorized Agent: