Aromadendrane and alloaromedendrane-type sesquiterpenoids from the roots and rhizomes of Valeriana officinalis var. latifolia and their biological activities

  • Fitoterapia. 2026 Apr:190:107144. doi: 10.1016/j.fitote.2026.107144.
Jia-Jin Liu  1 ,  Sheng-Run Guo  1 ,  Li-Zhong Wang  1 ,  Dan Liu  1 ,  Hong-Mei Li  2 ,  Rong-Tao Li  3
Affiliations
  • 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, PR China.
  • 2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, PR China. Electronic address: [email protected].
  • 3. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, PR China. Electronic address: [email protected].
PMID: 41707879 DOI: 10.1016/j.fitote.2026.107144
Abstract

Twelve previously undescribed aromadendrane and alloaromedendrane-type sesquiterpenoids, valeralins A-L (1-12), together with three known ones were isolated from the roots and rhizomes of Valeriana officinalis var. latifolia. Among them, compound 12 was the first aromadendrane-type norsesquiterpenoid with hemiacetal moiety. Their structures were elucidated based on spectroscopic analysis (1D and 2D NMR, and HRESIMS), as well as electronic circular dichroism (ECD) calculation. In addition, compound 7 exhibited in vitro anti-inflammatory activity on NO production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) with an IC50 value of 21.64 μM.

Keywords
Anti-inflammatory; Aromadendrane-type sesquiterpenoids; Caprifoliaceae; Valeriana officinalis var. latifolia.
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