1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

6-Maleimidohexanoic acid N-hydroxysuccinimide ester (Synonyms: EMCS)

Cat. No.: HY-78961 Purity: 98.05%
Handling Instructions

6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates.

For research use only. We do not sell to patients.

6-Maleimidohexanoic acid N-hydroxysuccinimide ester Chemical Structure

6-Maleimidohexanoic acid N-hydroxysuccinimide ester Chemical Structure

CAS No. : 55750-63-5

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50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 130 In-stock
Estimated Time of Arrival: December 31
500 mg USD 260 In-stock
Estimated Time of Arrival: December 31
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Description

6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates[1].

IC50 & Target

Non-cleavable

 

In Vitro

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.29

Formula

C₁₄H₁₆N₂O₆

CAS No.

55750-63-5

SMILES

O=C(C=C1)N(CCCCCC(ON2C(CCC2=O)=O)=O)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (324.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2437 mL 16.2185 mL 32.4370 mL
5 mM 0.6487 mL 3.2437 mL 6.4874 mL
10 mM 0.3244 mL 1.6218 mL 3.2437 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (24.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 7.5 mg/mL (24.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (24.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

6-Maleimidohexanoic acid N-hydroxysuccinimide esterEMCSADC LinkerAntibody-drug conjugates linkeraminosulfhydrylgroupscross-linkingreagentenzymeimmunoconjugateshaptenconjugateInhibitorinhibitorinhibit

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Product Name:
6-Maleimidohexanoic acid N-hydroxysuccinimide ester
Cat. No.:
HY-78961
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