1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Fmoc-Val-Cit-PAB-PNP

Fmoc-Val-Cit-PAB-PNP 

Cat. No.: HY-41189 Purity: 95.87%
Handling Instructions

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Fmoc-Val-Cit-PAB-PNP Chemical Structure

Fmoc-Val-Cit-PAB-PNP Chemical Structure

CAS No. : 863971-53-3

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Free Sample (0.5-1 mg)   Apply Now  
50 mg USD 140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable

 

Molecular Weight

766.80

Formula

C₄₀H₄₂N₆O₁₀

CAS No.

863971-53-3

Sequence Shortening

Fmoc-V-Cit-PAB-PNP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Stored under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (52.16 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3041 mL 6.5206 mL 13.0412 mL
5 mM 0.2608 mL 1.3041 mL 2.6082 mL
10 mM 0.1304 mL 0.6521 mL 1.3041 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.25 mg/mL (6.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fmoc-Val-Cit-PAB-PNPADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
Fmoc-Val-Cit-PAB-PNP
Cat. No.:
HY-41189
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