2. Metabolic Enzyme/Protease Others
  3. Fructose-1,6-bisphosphate aldolase Biochemical Assay Reagents
  4. GMBS

GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins.

For research use only. We do not sell to patients.

GMBS

GMBS Chemical Structure

CAS No. : 80307-12-6

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Based on 1 publication(s) in Google Scholar

GMBS Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins[1].

In Vitro

GMBS generates non-redundant and structurally compatible cross-links in BSA, aldolase, and yeast CNG protein subcomplexes[1].
GMBS generates a small amount of complementary cross-links in crude E. coli 70S ribosomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GMBS Related Antibodies
Molecular Weight

280.23

Formula

C12H12N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(CCC1=O)=O)CCCN2C(C=CC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (178.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5685 mL 17.8425 mL 35.6850 mL
5 mM 0.7137 mL 3.5685 mL 7.1370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.66%

SDS (394 KB)

COA (252 KB) HNMR (166 KB) LCMS (322 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5685 mL 17.8425 mL 35.6850 mL 89.2124 mL
5 mM 0.7137 mL 3.5685 mL 7.1370 mL 17.8425 mL
10 mM 0.3568 mL 1.7842 mL 3.5685 mL 8.9212 mL
15 mM 0.2379 mL 1.1895 mL 2.3790 mL 5.9475 mL
20 mM 0.1784 mL 0.8921 mL 1.7842 mL 4.4606 mL
25 mM 0.1427 mL 0.7137 mL 1.4274 mL 3.5685 mL
30 mM 0.1189 mL 0.5947 mL 1.1895 mL 2.9737 mL
40 mM 0.0892 mL 0.4461 mL 0.8921 mL 2.2303 mL
50 mM 0.0714 mL 0.3568 mL 0.7137 mL 1.7842 mL
60 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.4869 mL
80 mM 0.0446 mL 0.2230 mL 0.4461 mL 1.1152 mL
100 mM 0.0357 mL 0.1784 mL 0.3568 mL 0.8921 mL
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GMBS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GMBS80307-12-6Fructose-1,6-bisphosphate aldolaseBiochemical Assay ReagentsFructose-1,6-bisphosphate aldolase (FBA)E. coli 70S ribosomesaldolaseribosomal proteinsRosetta-based protein complex dockingprimary aminesprotein-protein interactionBSAyeast CNG protein subcomplexamino acid residuessulfhydryl groupsInhibitorinhibitorinhibit

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