NH2-MPAA-NODA TFA

Cat. No.: HY-135859A: Data Sheet
SDS
Handling Instructions
FAQs
Technical Support

NH2-MPAA-NODA TFA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone. NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

For research use only. We do not sell to patients.

NH2-MPAA-NODA TFA Chemical Structure

Size		Stock
MOQ		Minimum order quantity
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100 mg		Get quote
250 mg		Get quote
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Other Forms of NH2-MPAA-NODA TFA:

NH2-MPAA-NODA Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

NH2-MPAA-NODA TFA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone^[1]. NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

In Vitro

NH2-MPAA-NODA TFA contains the 1,4,7-triazacyclononane-1,4-diacetate (NODA) motif with a methyl phenyl acetic acid (MPAA) backbone, and it has enough ability to form stable Al18F-chelates.
NH2-MPAA-NODA can be conjugated to some inhibitors/antagonists labeled with ¹⁸F for PET imaging of targeting tumors. It also can be used as a radiolabel of peptides^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

549.54

Formula

C₂₃H₃₄F₃N₅O₇

Appearance

Solid

SMILES

O=C(NCCN)CC1=CC=C(C=C1)CN2CCN(CC(O)=O)CCN(CC(O)=O)CC2.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (181.97 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8197 mL	9.0985 mL	18.1970 mL
5 mM	0.3639 mL	1.8197 mL	3.6394 mL
10 mM	0.1820 mL	0.9099 mL	1.8197 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Data Sheet (270 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Daniel Kang, et al. Labelling via [Al18F]2+ Using Precomplexed Al-NODA Moieties. Pharmaceuticals 2021, 14(8), 818.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.8197 mL	9.0985 mL	18.1970 mL	45.4926 mL
	5 mM	0.3639 mL	1.8197 mL	3.6394 mL	9.0985 mL
	10 mM	0.1820 mL	0.9099 mL	1.8197 mL	4.5493 mL
	15 mM	0.1213 mL	0.6066 mL	1.2131 mL	3.0328 mL
	20 mM	0.0910 mL	0.4549 mL	0.9099 mL	2.2746 mL
	25 mM	0.0728 mL	0.3639 mL	0.7279 mL	1.8197 mL
	30 mM	0.0607 mL	0.3033 mL	0.6066 mL	1.5164 mL
	40 mM	0.0455 mL	0.2275 mL	0.4549 mL	1.1373 mL
	50 mM	0.0364 mL	0.1820 mL	0.3639 mL	0.9099 mL
	60 mM	0.0303 mL	0.1516 mL	0.3033 mL	0.7582 mL
	80 mM	0.0227 mL	0.1137 mL	0.2275 mL	0.5687 mL
	100 mM	0.0182 mL	0.0910 mL	0.1820 mL	0.4549 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

NH2-MPAA-NODA TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-MPAA-NODAADC LinkerAntibody-drug conjugates linkerphotocleavable linker,NODA motifradiolabelInhibitorinhibitorinhibit

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