NH2-MPAA-NODA

Cat. No.: HY-135859: Data Sheet
COA

SDS
Handling Instructions
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NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone. NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

For research use only. We do not sell to patients.

NH2-MPAA-NODA Chemical Structure

CAS No. : 2705545-44-2

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Other Forms of NH2-MPAA-NODA:

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Description

NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone^[1]. NH2-MPAA-NODA can be used as a radiolabel by labeling with ¹⁸F-fluoride.

IC₅₀ & Target

IC50: Nitroveratryl-based photocleavable linker

In Vitro

NH2-MPAA-NODA contains the 1,4,7-triazacyclononane-1,4-diacetate (NODA) motif with a methyl phenyl acetic acid (MPAA) backbone, and it has enough ability to form stable Al18F-chelates.
NH2-MPAA-NODA can be conjugated to some inhibitors/antagonists labeled with ¹⁸F for PET imaging of targeting tumors. It also can be used as a radiolabel of peptides^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

435.52

Formula

C₂₁H₃₃N₅O₅

CAS No.

2705545-44-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCN)CC1=CC=C(C=C1)CN2CCN(CC(O)=O)CCN(CC(O)=O)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥97.0%

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Data Sheet (265 KB) SDS (251 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Daniel Kang, et al. Labelling via [Al18F]2+ Using Precomplexed Al-NODA Moieties. Pharmaceuticals 2021, 14(8), 818.

NH2-MPAA-NODA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-MPAA-NODA2705545-44-2ADC LinkerAntibody-drug conjugates linkerCleavable,linkertumorradiolabelpeptidefluorideInhibitorinhibitorinhibit

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