2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DBCO-NHS ester

DBCO-NHS ester 

Cat. No.: HY-42973 Purity: 99.26%
COA Handling Instructions

DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DBCO-NHS ester Chemical Structure

DBCO-NHS ester Chemical Structure

CAS No. : 1353016-71-3

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10 mg USD 65 In-stock
50 mg USD 160 In-stock
100 mg USD 270 In-stock
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Based on 3 publication(s) in Google Scholar

DBCO-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

View All Isoforms
Cleavable Non-cleavable Acid Cleavable Disulfide Cleavable Protease Cleavable Glycosidase Cleavable Phosphatase Cleavable

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-NHS ester Related Antibodies
Molecular Weight

402.40

Appearance

Solid

Formula

C23H18N2O5
CAS No.
SMILES

O=C(CCC(ON(C(CC1)=O)C1=O)=O)N(C(C=CC=C2)=C2C#C3)CC4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (124.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4851 mL 12.4254 mL 24.8509 mL
5 mM 0.4970 mL 2.4851 mL 4.9702 mL
10 mM 0.2485 mL 1.2425 mL 2.4851 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.53%

COA (252 KB) HNMR (265 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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DBCO-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DBCO-NHS ester1353016-71-3ADC LinkerAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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DBCO-NHS ester
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