1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. DBCO-NHS ester

DBCO-NHS ester 

Cat. No.: HY-42973 Purity: 99.00%
Handling Instructions

DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DBCO-NHS ester Chemical Structure

DBCO-NHS ester Chemical Structure

CAS No. : 1353016-71-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

DBCO-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.40

Formula

C₂₃H₁₈N₂O₅

CAS No.

1353016-71-3

SMILES

O=C(N1CC2=CC=CC=C2C#CC3=CC=CC=C31)CCC(ON4C(CCC4=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4851 mL 12.4254 mL 24.8509 mL
5 mM 0.4970 mL 2.4851 mL 4.9702 mL
10 mM 0.2485 mL 1.2425 mL 2.4851 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DBCO-NHS esterADC LinkerAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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Product Name:
DBCO-NHS ester
Cat. No.:
HY-42973
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