1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. DBCO-Maleimide

DBCO-Maleimide 

Cat. No.: HY-116270
Handling Instructions

DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DBCO-Maleimide Chemical Structure

DBCO-Maleimide Chemical Structure

CAS No. : 1395786-30-7

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50 mg USD 880 Ask For Quote & Lead Time
100 mg USD 1400 Ask For Quote & Lead Time
250 mg USD 2750 Ask For Quote & Lead Time

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Description

DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

427.45

Formula

C₂₅H₂₁N₃O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (292.43 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3395 mL 11.6973 mL 23.3945 mL
5 mM 0.4679 mL 2.3395 mL 4.6789 mL
10 mM 0.2339 mL 1.1697 mL 2.3395 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
DBCO-Maleimide
Cat. No.:
HY-116270
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