DBCO-PEG5-NHS ester

Name: DBCO-PEG5-NHS ester
Brand: MedChemExpress
SKU: HY-126885
Rating: 4.5 (1 reviews)

Cat. No.: HY-126885 Purity: 95.06%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG5-NHS ester Chemical Structure

CAS No. : 2144395-59-3

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]^[2]. DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target^[1]^[2]

Cleavable Linker

Alkyl/ether

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

693.74

Formula

C₃₆H₄₃N₃O₁₁

CAS No.

2144395-59-3

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (144.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4415 mL	7.2073 mL	14.4146 mL
5 mM	0.2883 mL	1.4415 mL	2.8829 mL
10 mM	0.1441 mL	0.7207 mL	1.4415 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.06%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (260 KB) HNMR (318 KB) RP-HPLC (254 KB) MS (177 KB)

Handling Instructions (2659 KB)

References

[1]. Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.

[2]. Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4415 mL	7.2073 mL	14.4146 mL	36.0366 mL
	5 mM	0.2883 mL	1.4415 mL	2.8829 mL	7.2073 mL
	10 mM	0.1441 mL	0.7207 mL	1.4415 mL	3.6037 mL
	15 mM	0.0961 mL	0.4805 mL	0.9610 mL	2.4024 mL
	20 mM	0.0721 mL	0.3604 mL	0.7207 mL	1.8018 mL
	25 mM	0.0577 mL	0.2883 mL	0.5766 mL	1.4415 mL
	30 mM	0.0480 mL	0.2402 mL	0.4805 mL	1.2012 mL
	40 mM	0.0360 mL	0.1802 mL	0.3604 mL	0.9009 mL
	50 mM	0.0288 mL	0.1441 mL	0.2883 mL	0.7207 mL
	60 mM	0.0240 mL	0.1201 mL	0.2402 mL	0.6006 mL
	80 mM	0.0180 mL	0.0901 mL	0.1802 mL	0.4505 mL
	100 mM	0.0144 mL	0.0721 mL	0.1441 mL	0.3604 mL