2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DBCO-Sulfo-NHS ester sodium

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-Sulfo-NHS ester sodium Chemical Structure

DBCO-Sulfo-NHS ester sodium Chemical Structure

CAS No. : 1400191-52-7

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Based on 1 publication(s) in Google Scholar

DBCO-Sulfo-NHS ester sodium Related Antibodies

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Description

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target[1]

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-Sulfo-NHS ester sodium Related Antibodies
Molecular Weight

532.50

Formula

C25H21N2NaO8S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCC(N2C3=CC=CC=C3C#CC4=CC=CC=C4C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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DBCO-Sulfo-NHS ester sodium Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-Sulfo-NHS ester1400191-52-7ADC LinkerAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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