CD38 Protein, Human (HEK293, mFc)
The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, mFc) is the recombinant human-derived CD38 protein, expressed by HEK293, with C-mFc labeled tag.
- Species: Human
- Source: HEK293
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, mFc) is the recombinant human-derived CD38 protein, expressed by HEK293, with C-mFc labeled tag.
The CD38 Protein assumes a pivotal role in cellular signaling, being a proficient synthesizer of cyclic ADP-ribose (cADPR), a recognized second messenger crucial for glucose-induced insulin secretion. Moreover, it facilitates the synthesis of the calcium mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), derived from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. Operating at both pH 5.0 and pH 7.4, CD38 Protein exhibits a preference for transforming 2'-phospho-cADPR into NAADP(+) while selectively cleaving NADP(+) to cADPR and ADPRP rather than generating NADDP(+). Notably, it also showcases cADPR hydrolase activity, highlighting its multifaceted role in the dynamic regulation of these crucial signaling molecules. The integration of these activities underscores the significance of CD38 Protein in modulating cellular responses, particularly in the context of insulin secretion and calcium mobilization.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-mFc
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Accession
P28907-1 (V43-I300)
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Gene ID592
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Molecular Construction
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N-term
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CD38 (V43-I300)
Accession # P28907-1 -
mFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CD38; NAD(+) Nucleosidase; CD38 Molecule; CD38 Antigen (P45); ADP-Ribosyl Cyclase 1; ADPRC 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase; 2'-Phospho-Cyclic-ADP-Ribose Transferase; Cluster Of Di
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AA Sequence
VPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
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Predicted Molecular Mass
45 kDa
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Molecular Weight
Approximately 55-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Structure/Form
Monomer
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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