Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production

  • Bull Exp Biol Med. 2011 Jan;150(3):340-2. doi: 10.1007/s10517-011-1137-y.
P F Zabrodskii  1
Affiliations
  • 1. Saratov Military Institute of Biological and Chemical Safety, Russia. [email protected]
PMID: 21240349 DOI: 10.1007/s10517-011-1137-y
Abstract

Experiments on outbred mice showed that acetylcholine chloride in a dose of 20 mg/kg 6 h after subcutaneous injection significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×10(9) E. coli Bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.

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