GPR114 Protein, Human (HEK293, Fc)

GPR114, an adhesion G protein-coupled receptor (GPCR), crucially activates the adenylate cyclase pathway by coupling with G(s) subunit alpha. Isoform 1, displaying constitutive activity, elevates basal cyclic AMP (cAMP) levels and responds to mechanical stimulation, emphasizing GPR114's functional significance in intracellular signaling cascades and its role in cellular responses to mechanical cues. GPR114 Protein, Human (HEK293, Fc) is the recombinant human-derived GPR114 protein, expressed by HEK293, with C-hFc labeled tag. The total length of GPR114 Protein, Human (HEK293, Fc) is 163 a.a., with molecular weight of 56-63 kDa.

GPR114 is an adhesion G protein-coupled receptor (GPCR) that plays a key role in signal transduction by coupling with the G(s) subunit alpha of guanine nucleotide-binding proteins and activating the adenylate cyclase pathway. Notably, isoform 1 exhibits constitutive activity, leading to elevated basal levels of cyclic AMP (cAMP), and demonstrates responsiveness to mechanical stimulation, such as shaking. This highlights the functional significance of GPR114 in mediating intracellular signaling cascades and suggests its involvement in cellular responses to mechanical cues.

Human

HEK293

C-hFc

Q8IZF4 (E22-G184)

221188  [NCBI]

56-63 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.