ADGRG5 - adhesion G protein-coupled receptor G5 Gene

Homo sapiens

Also known as PGR27; GPR114

Gene ID: 221188 | Gene type: protein coding

About ADGRG5

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,529,073-57,577,189 (from NCBI)

This gene has 7 transcripts (splice variants), 113 orthologues and 42 paralogues. Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues.

Summary

This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

ADGRG5 Products(3)

mRNA	Protein	Name
NM_001304376.3	NP_001291305.1	adhesion G-protein coupled receptor G5 isoform 1 precursor
NM_001318481.2	NP_001305410.1	adhesion G-protein coupled receptor G5 isoform 2 precursor
NM_153837.4	NP_722579.1	adhesion G-protein coupled receptor G5 isoform 1 precursor

ADGRG5 Protein Structure

GPS

7tm_2

0
100
200
300
400
500
528 a.a.

Protein Preferred Names

Protein Names

adhesion G-protein coupled receptor G5

G protein-coupled receptor 114

Recombinant ADGRG5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76960	GPR114 Protein, Human (HEK293, Fc)	Q8IZF4 (E22-G184)	≥95%

Related Diseases

Diseases

Alias

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Alveoli Adenoma

Alveolar Adenoma	Adenoma Of Alveoli
Adenoma Of The Alveoli

Bronchial Benign Neoplasm

Bronchus Neoplasm	Neoplasm Of Bronchus
Bronchial Neoplasms	Bronchial Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101483	Dihydromunduletone	Antagonist	99.96%	Unkown
HY-RS00358	ADGRG5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADGRG5	VGNC	VGNC:25668
Rattus norvegicus	ADGRG5	RGD	RGD:1305559
Macaca mulatta	ADGRG5	VGNC	VGNC:69634
Felis catus	ADGRG5	VGNC	VGNC:59636
Mus musculus	ADGRG5	MGD	MGI:2685955
Canis familiaris	ADGRG5	VGNC	VGNC:37647
Others	ADGRG5	NCBI

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