ADGRG5 - adhesion G protein-coupled receptor G5 Gene

Also Known as PGR27; GPR114

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221188

About ADGRG5

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,529,073-57,577,189 (from NCBI)

This gene has 7 transcripts (splice variants), 113 orthologues and 42 paralogues. Biased expression in lymph node (RPKM 4.6), spleen (RPKM 3.3) and 13 other tissues.

Summary

This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

ADGRG5 Products (3)

mRNA	Protein	Name
NM_001304376.3	NP_001291305.1	adhesion G-protein coupled receptor G5 isoform 1 precursor
NM_001318481.2	NP_001305410.1	adhesion G-protein coupled receptor G5 isoform 2 precursor
NM_153837.4	NP_722579.1	adhesion G-protein coupled receptor G5 isoform 1 precursor

ADGRG5 Protein Structure

GPS

7tm_2

0
100
200
300
400
500
528 a.a.

Protein Preferred Names	Protein Names
adhesion G-protein coupled receptor G5	G protein-coupled receptor 114

Recombinant ADGRG5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76960	GPR114 Protein, Human (HEK293, Fc)	Q8IZF4 (E22-G184)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Polymicrogyria, Bilateral Frontoparietal	Bilateral Frontoparietal Polymicrogyria BFPP Cerebellar Ataxia With Neuronal Migration Defect
Usher Syndrome, Type Iic	Usher Syndrome Type 2c USH2C Usher Syndrome, Type 2c Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic Usher Syndrome Type Iic Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic Usher Syndrome 2c Usher'S Syndrome Type 2c Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Alveoli Adenoma	Alveolar Adenoma Adenoma Of Alveoli Adenoma Of The Alveoli
Bronchial Benign Neoplasm	Bronchus Neoplasm Neoplasm Of Bronchus Bronchial Neoplasms Bronchial Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101483	Dihydromunduletone		99.23%	Unkown
HY-175232	GL64		98.80%	Unkown
HY-RS00358	ADGRG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20523	Adgrg5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27032	Adgrg5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADGRG5	VGNC	VGNC:25668
Rattus norvegicus	ADGRG5	RGD	RGD:1305559
Macaca mulatta	ADGRG5	VGNC	VGNC:69634
Felis catus	ADGRG5	VGNC	VGNC:59636
Mus musculus	ADGRG5	MGD	MGI:2685955
Canis familiaris	ADGRG5	VGNC	VGNC:37647
Others	ADGRG5	NCBI