IL-18 Protein, Rhesus Macaque

IL-18 protein is a pro-inflammatory cytokine that is critically involved in epithelial barrier repair and regulates immune responses, especially Th1 cell and NK cell immune responses. IL-18 binds to IL18R1 and IL18RAP receptors to form a signaling ternary complex, activate NF-κ-B, and induce inflammatory mediators. IL-18 Protein, Rhesus Macaque is the recombinant Rhesus Macaque-derived IL-18 protein, expressed by E. coli.

IL-18 Protein is a pro-inflammatory cytokine that plays a crucial role in epithelial barrier repair and the modulation of immune responses, specifically in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to its receptors IL18R1 and IL18RAP, IL-18 forms a signaling ternary complex that activates NF-kappa-B, resulting in the synthesis of inflammatory mediators. It also works synergistically with IL-12/interleukin-12 to induce the synthesis of IFNG from Th1 cells and NK cells. Furthermore, IL-18 is involved in transducing inflammation downstream of pyroptosis, where its mature form is selectively released into the extracellular space through the gasdermin-D (GSDMD) pore.

Rhesus Macaque

E. coli

Tag Free

Q9BGI5/NP_001028006.1 (Y37-D193)

574151

Full Length of Mature Protein (with Propeptide)

AAEPAEDNCINFVAMKFIDSTLYFIAEDDENLESDYFGKLESKLSIIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIINMYKDSQPRGMAVAISVKCEKISTLSCENRIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLYKLILKKKDELGDRSIMFTVQNED

Approximately 15-17 kDa, based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.