1. MAPK/ERK Pathway
  2. Mixed Lineage Kinase
  3. MLK-IN-1

MLK-IN-1 

Cat. No.: HY-111351
Handling Instructions

MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1.

For research use only. We do not sell to patients.

MLK-IN-1 Chemical Structure

MLK-IN-1 Chemical Structure

CAS No. : 1627729-62-7

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Description

MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1[1].

IC50 & Target[1]

MLK3

 

In Vitro

MLK-IN-1 (100 nM; pre-treatment 20 mins HIV-1 Tat) promotes continued axonogenesis in the presence of Tat-activated microglia and protects against effects of HIV-Tat in vitro[1].

Molecular Weight

432.49

Formula

C₂₃H₂₀N₄O₃S

CAS No.

1627729-62-7

SMILES

COC1=C2C(C=C(C3=CN=C4C=CC(NC5=CC=C(OC)C(OC)=C5)=NN43)S2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MLK-IN-1Mixed Lineage KinaseMLKsimidazopyridineAxonogenesismicrogliaE18primaryhippocampal neuronHIV-TataxonogenesisInhibitorinhibitorinhibit

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