1. MAPK/ERK Pathway
    Protein Tyrosine Kinase/RTK
  2. Mixed Lineage Kinase
    VEGFR
  3. GW806742X hydrochloride

GW806742X hydrochloride 

Cat. No.: HY-112292A Purity: 98.77%
Handling Instructions

GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC50=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis.

For research use only. We do not sell to patients.

GW806742X hydrochloride Chemical Structure

GW806742X hydrochloride Chemical Structure

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 81 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
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10 mg USD 80 In-stock
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25 mg USD 150 In-stock
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50 mg USD 250 In-stock
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100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GW806742X hydrochloride:

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Description

GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC50=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis[1][2].

IC50 & Target[1][2]

MLKL

9.3 μM (Kd)

VEGFR2

2 nM (IC50)

In Vitro

GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner[1].
GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

610.01

Formula

C₂₅H₂₃ClF₃N₇O₄S

SMILES

[H]Cl.O=S(C1=CC=CC(NC2=NC=CC(N(C)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3)=N2)=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (163.93 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6393 mL 8.1966 mL 16.3932 mL
5 mM 0.3279 mL 1.6393 mL 3.2786 mL
10 mM 0.1639 mL 0.8197 mL 1.6393 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

GW806742XMixed Lineage KinaseVEGFRMLKsVascular endothelial growth factor receptorTSQnecroptoticdeathHUVECmembranetranslocationInhibitorinhibitorinhibit

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Product Name:
GW806742X hydrochloride
Cat. No.:
HY-112292A
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