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GW806742X hydrochloride

25 Cited Publications
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Based on 25 publication(s) in Google Scholar

GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC50=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis.

For research use only. We do not sell to patients.

  • Purity: 98.30%
  • CAS No.: 2930350-95-9
  • Formula: C25H23ClF3N7O4S
  • Molecular Weight:610.01
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • GW806742X hydrochloride Chemical Structure
    GW806742X hydrochloride Chemical Structure
  • Experimental Validation Results for GW806742X hydrochloride
  • Experimental Validation Results for GW806742X hydrochloride
  • Experimental Validation Results for GW806742X hydrochloride
  • Experimental Validation Results for GW806742X hydrochloride
  • Experimental Validation Results for GW806742X hydrochloride
  • Experimental Validation Results for GW806742X hydrochloride
CAS No.: 2930350-95-9
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Cell Proliferation/Viability AssayWBIHCIn Vivo Imaging
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  • GW806742X hydrochloride Chemical Structure
    GW806742X hydrochloride Chemical Structure
    1/16
  • 1/16

    GW806742X hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 18;15(1):6043. [Abstract]

    Customer Validation
     WB analysis of necroptosis markers after 48 h treatment with different necroptosis inhibitors. The inhibitors used were Nec-1 (50 µM, a RIPK1 inhibitor), GSK-872 (3 µM, a RIPK3 inhibitor), and GW806742X (1 µM, an MLKL inhibitor).

  • 1/16

    GW806742X hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 18;15(1):6043. [Abstract]

    Customer Validation
     WB analysis of PCNA in cells untreated/treated with GW806742X (1 µM) for 48 h.

  • 1/16

    GW806742X hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 18;15(1):6043. [Abstract]

    Customer Validation
     CD47 IHC staining of primary tumours from C57BL/6 orthotopic model received different treatments: saline, anti-mouse IL6 (200 µg, iv., 3×/week), or GW806742X (100 µM in 50 µl, iv., 3×/week); mice were euthanized 4 weeks after injection.

  • 1/16

    GW806742X hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 18;15(1):6043. [Abstract]

    Customer Validation
     Bioluminescence of total tumour burden in C57BL/6 orthotopic model received different treatments: saline, GW806742X (100 µM in 50 µl, iv., 3×/week), anti-mCD47 (400 µg, ip., 3×/week) or both since day 7 after injection (106 KPC OE-MLKL cells); Images were collected at four weeks after injection; (8 mice per group).

  • 1/16

    GW806742X hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2023 Mar;615(7950):158-167. [Abstract]

    Customer Validation
     Cell viability assessment in Tbk1-null B16 cells pre-treated with RIPK3 inhibitor (HS-1371, 2 μM) or MLKL inhibitor (GW806742X, 5 μM) and the pan-caspase inhibitor Q-VD-Oph (20 μM) +/− TNFα/IFNγ for 9 days (n=6, 2 independent experiments: 2-way ANOVA, Dunnett’s multiple comparisons test).

  • 1/16

    GW806742X hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2022 Apr;18(4):726-744. [Abstract]

    Customer Validation
     Western blots for levels of p-MLKL and MLKL in wild type (WT) L929 cells untreated or treated with either TSZ for 6 h or ECS for 3 h. GW806742X (GW, 1 µM) was included in some samples as indicated 0.5 h before and during the treatment.

  • GW806742X hydrochloride