Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3519-23. doi: 10.1016/j.bmcl.2005.05.096.
Douglas M Sammond  1 ,  Kristen E Nailor ,  James M Veal ,  Robert T Nolte ,  Liping Wang ,  Victoria B Knick ,  Sharon K Rudolph ,  Anne T Truesdale ,  Eldridge N Nartey ,  Jeffrey A Stafford ,  Rakesh Kumar ,  Mui Cheung
Affiliations
  • 1. GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]
PMID: 15990302 DOI: 10.1016/j.bmcl.2005.05.096
Abstract

A series of dianilinopyrimidineureas demonstrate potency as VEGFR2 kinase inhibitors.

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