1. MAPK/ERK Pathway
    Protein Tyrosine Kinase/RTK
  2. Mixed Lineage Kinase
    VEGFR
  3. GW806742X

GW806742X 

Cat. No.: HY-112292
Handling Instructions

GW806742X is a Mixed Lineage Kinase Domain-Like (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and anti-necroptosis activity. GW806742X has activity against VEGFR2.

For research use only. We do not sell to patients.

GW806742X Chemical Structure

GW806742X Chemical Structure

CAS No. : 579515-63-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 126 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 690 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GW806742X is a Mixed Lineage Kinase Domain-Like (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and anti-necroptosis activity. GW806742X has activity against VEGFR2[1][2].

IC50 & Target

Kd: 9.3 μM (MLKL)[1]

Storage

4°C, sealed storage, away from moisture

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (217.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7435 mL 8.7176 mL 17.4353 mL
5 mM 0.3487 mL 1.7435 mL 3.4871 mL
10 mM 0.1744 mL 0.8718 mL 1.7435 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

573.55

Formula

C₂₅H₂₂F₃N₇O₄S

CAS No.

579515-63-2

SMILES

O=S(C1=CC=CC(NC2=NC=CC(N(C)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3)=N2)=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GW806742X
Cat. No.:
HY-112292
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GW806742X

Cat. No.: HY-112292