PDGF-CC Protein, Human (HEK293, Fc)

PDGF-CC, a multifaceted growth factor, assumes a pivotal role in orchestrating diverse cellular processes, including embryonic development, cell proliferation, migration, survival, and chemotaxis. As a potent mitogen and chemoattractant for mesenchymal cells, PDGF-CC is indispensable for the normal formation of the embryonic skeleton, particularly the craniofacial skeleton and palate. Its significance extends to skin morphogenesis during embryonic development and holds a critical position in wound healing, guiding the intricate stages of inflammation, proliferation, and remodeling. Moreover, PDGF-CC emerges as a key player in angiogenesis, blood vessel development, and fibrotic processes, where it contributes to the transformation of interstitial fibroblasts into myofibroblasts and collagen deposition. Beyond its role in maintaining PDGF domain latency, the CUB domain exhibits mitogenic activity in coronary artery smooth muscle cells. Intriguingly, within the nucleus, PDGF-CC appears to serve additional functions. Structurally, PDGF-CC forms homodimers linked by disulfide bonds and engages in interactions with PDGFRA homodimers, as well as heterodimers formed by PDGFRA and PDGFRB, highlighting its intricate involvement in a myriad of cellular activities. The CUB domain of PDGF-CC further interacts with PLAT, emphasizing its diverse and dynamic roles in cellular regulation.