PDGFC - platelet derived growth factor C Gene

Also Known as SCDGF; FALLOTEIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56034

About PDGFC

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:156,760,454-156,971,799 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 16.6), prostate (RPKM 13.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

PDGFC Products (1)

mRNA Protein Name
NM_016205.3 NP_057289.1 platelet-derived growth factor C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables platelet-derived growth factor receptor binding IPI
IPI: Inferred from physical interaction
10806482 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10806482 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10806482 GOA
Biological Process GO Annotation Evidence References Source
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
10806482 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10806482 GOA
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
10806482 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
10806482 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
10806482 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFC Protein Structure

CUB

CUB: CUB domain (53 - 160)

PDGF

PDGF: PDGF/VEGF domain (250 - 337)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

platelet-derived growth factor C

  • PDGF-C

PDGFC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDGFC Q9NRA1 PDGFRA Homo sapiens P16234
Competition Binding
10806482
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDGFC Proteins

Cat. No. Product Name Accession Purity
HY-P7279 PDGF-CC Protein, Human (HEK293) Q9NRA1-1 (V235-G345) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73353 PDGF-CC Protein, Human (HEK293, Fc) Q9NRA1-1 (V235-G345) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Milker'S Nodule

  • Poxviridae Infections

  • Milker Nodule

  • Milkers' Node

  • Paravaccinia

  • Pseudocowpox

  • Milker'S Nodes
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Contagious Pustular Dermatitis

  • Ecthyma, Contagious

  • Orf

  • Ecthyma Contagiosum

  • Scabby Mouth

  • Sheep Pox

  • Thistle Disease

  • Contagious Pustular Dermatosis
Bronchiectasis 2
Petrous Apex Meningioma

  • Meningioma Of The Petrous Ridge
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Orofacial Cleft

  • Cleft, Orofacial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10252 PDGFC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174551 Human PDGFC mRNA / Unkown
HY-RS21686 Pdgfc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28204 Pdgfc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PDGFC VGNC VGNC:44370
Mus musculus PDGFC MGD MGI:1859631
Rattus norvegicus PDGFC RGD RGD:68410
Bos taurus PDGFC VGNC VGNC:53915
Macaca mulatta PDGFC VGNC VGNC:75928
Felis catus PDGFC VGNC VGNC:68771
Others PDGFC NCBI