PDGF-AB
PDGF-AB is the natural heterodimer formed when cells co-express the PDGF-A and PDGF-B chains, which assemble through interchain disulfide bonds. It occupies an intermediate position within the isoform family: it activates PDGFR-alpha and PDGFR-alpha/beta complexes but, unlike PDGF-BB, is a poor agonist of PDGFR-beta homodimers. Present in platelet releasate and certain tumor secretions, PDGF-AB stimulates fibroblast and glial cell proliferation and contributes to wound-healing and vascular-remodeling responses. Recombinant PDGF-AB is used to compare isoform-specific receptor activation, dose-response behavior in mitogenicity assays, and the pharmacology of PDGFR-targeted antibodies and tyrosine kinase inhibitors.
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PDGF-AB Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
