1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. UVI 3003

UVI 3003 

Cat. No.: HY-107500 Purity: >98.0%
Handling Instructions

UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.

For research use only. We do not sell to patients.

UVI 3003 Chemical Structure

UVI 3003 Chemical Structure

CAS No. : 847239-17-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 310 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively.

IC50 & Target

IC50: 0.22 μM (Xenopus RXRα, in Cos7 cells), 0.24 μM (Human RXRα, in Cos7 cells)[1]

In Vitro

UVI3003 inhibits the activity of xenopus and human RXRα, with IC50s of 0.22 and 0.24 μM, respectively. UVI3003 fully activates xPPARγ with an EC50 of 12.6 μM, and is almost completely inactive on hPPARγ and mPPARγ[1]. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression[2].

Molecular Weight

436.58

Formula

C₂₈H₃₆O₄

CAS No.

847239-17-2

SMILES

CCCCCOC1=C(C2=CC(/C=C\C(O)=O)=CC=C2O)C=C3C(C(C)(CCC3(C)C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (229.05 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2905 mL 11.4527 mL 22.9053 mL
5 mM 0.4581 mL 2.2905 mL 4.5811 mL
10 mM 0.2291 mL 1.1453 mL 2.2905 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[2]

At ∼30-40% confluence cells are treated with vehicle (ethanol), all-trans retinoic acid (1 μM), the RAR inverse agonist BMS493 (10 μM), or the RXR antagonist UVI 3003 (10 μM) for 24 h in proliferation media with a final concentration of ethanol at 0.1% for all treatments. At the end of the 24-h treatment cell proliferation rates are assessed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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UVI 3003
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