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Alectinib Hydrochloride

(Synonyms: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride)
44 Cited Publications
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Based on 44 publication(s) in Google Scholar

Alectinib (CH5424802; RO5424802; RG7853) Hydrochloride is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration.

For research use only. We do not sell to patients.

  • Purity: 99.92%
  • CAS No.: 1256589-74-8
  • Formula: C30H35ClN4O2
  • Molecular Weight:519.08
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Alectinib Hydrochloride Chemical Structure
    Alectinib Hydrochloride Chemical Structure
  • Experimental Validation Results for Alectinib Hydrochloride
  • Experimental Validation Results for Alectinib Hydrochloride
  • Experimental Validation Results for Alectinib Hydrochloride
CAS No.: 1256589-74-8
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Alectinib Hydrochloride Chemical Structure
    Alectinib Hydrochloride Chemical Structure
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    Alectinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2018 May 10:4:56. [Abstract]

    Customer Validation
     NB39-nu cells are treated with either 1000 nM Crizotinib (CR) or Alectinib (AL) for the indicated times and subjected to immunoblot analysis. CLTC is the loading control.

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    Alectinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Aug 1:400:61-68. [Abstract]

    Customer Validation
     Alectinib inhibits PI3K/Akt/mTOR signaling and induces apoptosis in NB cells. NB-19, Kelly, IMR-32, SH-SY5Y, SK-N-AS and LA-N-6 cells are treated with 10 mM alectinib for various time points as indicated. The anti-b-Actin antibody is used as a loading control for whole cell extracts.

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    Alectinib Hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 Aug 1:400:61-68. [Abstract]

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     In contrast to tumors treated with DMSO, tumors treated with Alectinib exhibits significantly decreased levels of p-Akt and p-S6. Furthermore, increased PARP and Caspase 3 cleavages are observed in tumors treated with Alectinib compared to controls.

  • Alectinib Hydrochloride