2. Cytoskeleton Apoptosis
  3. Integrin Apoptosis
  4. RGD peptide (GRGDNP)

RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation.

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RGD peptide (GRGDNP) Chemical Structure

RGD peptide (GRGDNP) Chemical Structure

CAS No. : 114681-65-1

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Based on 3 publication(s) in Google Scholar

Other Forms of RGD peptide (GRGDNP):

RGD peptide (GRGDNP) Related Antibodies

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Description

RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3].

IC50 & Target[2]

α5β1

 

In Vitro

RGD peptide (GRGDNP) (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs[2].
RGD peptide (GRGDNP) (300 μg/mL; for 6 hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RGD peptide (GRGDNP) Related Antibodies
Molecular Weight

614.61

Formula

C23H38N10O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Arg-Gly-Asp-Asn-Pro
Sequence Shortening

GRGDNP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 3.12 mg/mL (5.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6270 mL 8.1352 mL 16.2705 mL
5 mM 0.3254 mL 1.6270 mL 3.2541 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6270 mL 8.1352 mL 16.2705 mL 40.6762 mL
5 mM 0.3254 mL 1.6270 mL 3.2541 mL 8.1352 mL
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RGD peptide (GRGDNP) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RGD peptide (GRGDNP)114681-65-1IntegrinApoptosisintegrin-ligand interactionsα5β1extracellular matriceECMpro-caspase-3autoprocessingadhesionmigrationgrowthdifferentiationIKKHT22 cellInhibitorinhibitorinhibit

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