RGD peptide (GRGDNP) (TFA)

Name: RGD peptide (GRGDNP) (TFA)
Brand: MedChemExpress
SKU: HY-P1740A
Rating: 4.5 (3 reviews)

Cat. No.: HY-P1740A Purity: 99.41%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

RGD peptide (GRGDNP) (TFA) Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 145	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of RGD peptide (GRGDNP) (TFA):

RGD peptide (GRGDNP) In-stock

3 Publications Citing Use of MCE RGD peptide (GRGDNP) (TFA)

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[2]

α5β1

In Vitro

RGD peptide (GRGDNP) TFA (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs^[2].
RGD peptide (GRGDNP) TFA (300 μg/mL; for 6 hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

728.63

Formula

C₂₅H₃₉F₃N₁₀O₁₂

Appearance

Solid

Color

White to off-white

Sequence

Gly-Arg-Gly-Asp-Asn-Pro

Sequence Shortening

GRGDNP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (68.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (68.62 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3724 mL	6.8622 mL	13.7244 mL
5 mM	0.2745 mL	1.3724 mL	2.7449 mL
10 mM	0.1372 mL	0.6862 mL	1.3724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (137.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (255 KB) LCMS (229 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)

References

[1]. C D Buckley, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11;397(6719):534-9. [Content Brief]

[2]. Wei Xia, et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12(1):6043. [Content Brief]

[3]. Akitoshi Sasamoto, et al. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol. 2005 May;288(5):C1012-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.3724 mL	6.8622 mL	13.7244 mL	34.3110 mL
	5 mM	0.2745 mL	1.3724 mL	2.7449 mL	6.8622 mL
	10 mM	0.1372 mL	0.6862 mL	1.3724 mL	3.4311 mL
	15 mM	0.0915 mL	0.4575 mL	0.9150 mL	2.2874 mL
	20 mM	0.0686 mL	0.3431 mL	0.6862 mL	1.7155 mL
	25 mM	0.0549 mL	0.2745 mL	0.5490 mL	1.3724 mL
	30 mM	0.0457 mL	0.2287 mL	0.4575 mL	1.1437 mL
	40 mM	0.0343 mL	0.1716 mL	0.3431 mL	0.8578 mL
	50 mM	0.0274 mL	0.1372 mL	0.2745 mL	0.6862 mL
	60 mM	0.0229 mL	0.1144 mL	0.2287 mL	0.5718 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.