1. Cytoskeleton
  2. Integrin

Cyclo(RGDyK) trifluoroacetate 

Cat. No.: HY-100563 Purity: 99.13%
Handling Instructions

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

For research use only. We do not sell to patients.

Cyclo(RGDyK) trifluoroacetate Chemical Structure

Cyclo(RGDyK) trifluoroacetate Chemical Structure

CAS No. : 250612-42-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 590 In-stock
Estimated Time of Arrival: December 31
100 mg USD 890 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

IC50 & Target

IC50: 20 nM (αVβ3 Integrin), 3000 nM (αIIbβ3 Integrin), 4000 nM (αVβ5 Integrin)[1]

In Vitro

Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 130 mg/mL (153.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1796 mL 5.8982 mL 11.7963 mL
5 mM 0.2359 mL 1.1796 mL 2.3593 mL
10 mM 0.1180 mL 0.5898 mL 1.1796 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (2.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.17 mg/mL (2.56 mM); Clear solution; Need warming

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (2.56 mM); Clear solution

References
Molecular Weight

847.72

Formula

C₃₁H₄₃F₆N₉O₁₂

CAS No.

250612-42-1

SMILES

O=C(N[[email protected]](C(N[[email protected]]1CCCNC(N)=N)=O)CCCCN)[[email protected]](NC([[email protected]@H](NC(CNC1=O)=O)CC(O)=O)=O)CC2=CC=C(O)C=C2.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Cyclo(RGDyK) trifluoroacetate
Cat. No.:
HY-100563
Quantity:

Cyclo(RGDyK) trifluoroacetate

Cat. No.: HY-100563