Cyclo(RGDyK)
Based on 4 publication(s) in Google Scholar
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.86%
- No. CAS: 217099-14-4
- Fòrmula: C27H41N9O8
- Peso molecular:619.67
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Almacenamiento:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Cyclo(RGDyK)
More
Actividad biológica
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αvβ3 20 nM (IC50) |
Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 217099-14-4
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Appearance Solid
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Peso molecular 619.67
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Fòrmula C27H41N9O8
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Color White to off-white
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Sequence
Cyclo(Arg-Gly-Asp-{d-Tyr}-Lys)
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Sequence Shortening
Cyclo(RGDyK)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (4)
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Journal Impact Factor
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Most Recent
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J Adv Res
Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease. [Abstract]2025 May 25:S2090-1232(25)00370-4. PMID: 40425084 -
Stem Cell Res Ther
Extracellular matrix derived from Wharton's Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin αVβ3/c-Myc/P300/VEGF. [Abstract]2022 Jul 18;13(1):327. PMID: 35851415 -
Biochem Pharmacol
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNFα/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells. [Abstract]2023 Nov:217:115808. PMID: 37716622 -
Pharmaceuticals (Basel)
Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis. [Abstract]2021 Mar 14;14(3):260. PMID: 33799345
Solvente y solubilidad
DMSO : 100 mg/mL (161.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (161.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.6138 mL | 8.0688 mL | 16.1376 mL | 40.3441 mL |
| 5 mM | 0.3228 mL | 1.6138 mL | 3.2275 mL | 8.0688 mL | |
| 10 mM | 0.1614 mL | 0.8069 mL | 1.6138 mL | 4.0344 mL | |
| 15 mM | 0.1076 mL | 0.5379 mL | 1.0758 mL | 2.6896 mL | |
| 20 mM | 0.0807 mL | 0.4034 mL | 0.8069 mL | 2.0172 mL | |
| 25 mM | 0.0646 mL | 0.3228 mL | 0.6455 mL | 1.6138 mL | |
| 30 mM | 0.0538 mL | 0.2690 mL | 0.5379 mL | 1.3448 mL | |
| 40 mM | 0.0403 mL | 0.2017 mL | 0.4034 mL | 1.0086 mL | |
| 50 mM | 0.0323 mL | 0.1614 mL | 0.3228 mL | 0.8069 mL | |
| 60 mM | 0.0269 mL | 0.1345 mL | 0.2690 mL | 0.6724 mL | |
| 80 mM | 0.0202 mL | 0.1009 mL | 0.2017 mL | 0.5043 mL | |
| 100 mM | 0.0161 mL | 0.0807 mL | 0.1614 mL | 0.4034 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclo(RGDyK) Related Classifications
HY-100563A Related Classifications
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