114681-65-1
Chemical Structure
RGD peptide (GRGDNP)
- CAS No.: 114681-65-1
- Formula:C23H38N10O10
- Molecular Weight:614.61
IUPAC Name: glycyl-L-arginylglycyl-L-aspartyl-L-asparaginyl-L-proline
InChIKey: CWAHAVYVGPRZJU-XUXIUFHCSA-N
SMILES: O=C(O)[C@H]1N(C([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CN)=O)=O)=O)=O)=O)CCC1
Biological Activity: RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RGD peptide (GRGDNP) | 99.83% | RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation. | ||||||||||||||||||||
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References
- [1]. C D Buckley, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11;397(6719):534-9. [Content Brief]
- [2]. Wei Xia, et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15;12(1):6043. [Content Brief]
- [3]. Akitoshi Sasamoto, et al. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol. 2005 May;288(5):C1012-22. [Content Brief]
