Integrin alpha V beta 3
Integrin alpha V beta 3, the vitronectin receptor, pairs CD51 with CD61 and is a hallmark of activated endothelium during angiogenesis. It binds RGD-containing ligands including vitronectin, fibrinogen, von Willebrand factor and osteopontin, and it is highly expressed on osteoclasts, where it is required for bone resorption. On tumor and angiogenic endothelial cells the receptor is strongly upregulated relative to quiescent vessels, making it one of the most exploited targets in vascular imaging: radiolabeled cyclic RGD peptides localize alpha V beta 3 for PET imaging of tumors. Therapeutically, cilengitide, a cyclic RGD peptidomimetic blocking alpha V beta 3 and alpha V beta 5, reached phase III trials in glioblastoma.
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Integrin alpha V beta 3 Recombinant Proteins (5)
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Inhibitors & Agonists (36)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
