2. Signaling Pathways
  3. Cytoskeleton
  4. Integrin
  5. Integrin Modulator

Integrin Modulator

Integrin Isoform Comparison

Integrin Modulators (6):

Cat. No. Product Name Effect Purity
  • HY-P3160
    Fibronectin
    		Modulator 98.70%
    Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans.
    This product is a human Fibronectin obtained by recombinant expression in a rice expression system.
  • HY-P6438
    Alkyne-cRGD
    		Modulator 99.48%
    Alkyne-cRGD is an integrin ligand. Alkyne-cRGD can be used in the study of degraders. Alkyne-cRGD undergoes copper-catalyzed azide-alkyne cycloaddition reaction.
  • HY-P0031
    Cyclo(RADfK)
    		Modulator
    Cyclo(RADfK) can be used as a control for Cyclo(-RGDfK) (HY-P0023).
  • HY-48959
    α7β1 integrin modulator-1
    		Modulator 98.02%
    α7β1 integrin modulator-1 is a potent α7β1 integrin modulator. α7β1 integrin modulator-1 has the potential for the research of muscular dystrophy.
  • HY-P10783
    BGC0222
    		Modulator
    BGC0222 is a novel prodrug of Irinotecan (HY-16562). BGC0222, as a PEG-cRGD-conjugated Irinotecan (HY-16562) derivative, could slowly and steadily release Irinotecan (HY-16562). BGC0222 binds to αVβ3 with IC50 values of 4.25 μM (αVβ3) and 58.7 μM (αVβ5). BGC0222 possesses the property of inducing neovascularization. BGC0222 exhibits good antiproliferation activity in many tumors.
  • HY-181606
    Cyclo(phg-isoDGR-k)-PEG4-non-cleavable-SAR405838
    		Modulator
    Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is a dual MDM2 and α5β1 integrin modulator. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 acts as an antiproliferative agent, apoptosis inducer and cell cycle regulator, induces reactivation of p53 and upregulation of p21, redistributes glioblastoma cells from the G0/G1 phase to the G2/M phase, and enhances apoptosis. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is applicable to the research of glioblastoma.