Cyclo(phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 

Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is a dual MDM2 and α5β1 integrin modulator. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 acts as an antiproliferative agent, apoptosis inducer and cell cycle regulator, induces reactivation of p53 and upregulation of p21, redistributes glioblastoma cells from the G₀/G₁ phase to the G₂/M phase, and enhances apoptosis. Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 is applicable to the research of glioblastoma^[1].

Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 (Compound 1) potently inhibits the viability of U87-MG glioblastoma cells at 72 h, with an IC₅₀ of 1.46 μM^[1].
Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 (0.1-10.0 μM; 24 h) upregulates p53 and p21 in a dose-dependent manner^[1].
Cyclo (phg-isoDGR-k)-PEG4-non-cleavable-SAR405838 (10.0 μM; 24 h) induces cell cycle arrest at the G2/M phase and generates a high proportion of apoptotic cell population in the sub-G1 phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1605.64

C₇₅H₁₀₄Cl₂FN₁₇O₁₇

O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5CC[C@H](OC(N(C)CCN(C)C(CCC6=CN(N=N6)CCOCCOCCOCCOCC(NCCCC[C@H](C(N[C@H](C7=CC=CC=C7)C(N[C@H](C(O)=O)C8)=O)=O)NC([C@H](CCCNC(N)=N)NC(CNC8=O)=O)=O)=O)=O)=O)CC5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Arrigoni F, et al. Synthesis and Biological Evaluation of a Novel Dual-Targeting Small Molecule Drug Conjugate Modulating the Crosstalk between α5β1 Integrin and MDM2 in Glioblastoma. ACS Med Chem Lett. 2026;17(2):450-457. Published 2026 Jan 19.  [Content Brief]