Integrin alpha 1 beta 1
Integrin alpha 1 beta 1 (VLA-1, CD49a/CD29) is an I-domain collagen receptor restricted largely to mesenchymal cells and activated immune cells. Its alpha-1 I-domain binds collagens I and IV as well as laminin in a metal-ion-dependent manner, anchoring fibroblasts, smooth muscle cells and activated T cells within connective tissue. The receptor appears on T cells only after activation and marks a tissue-retained effector population involved in delayed-type hypersensitivity and chronic inflammation. In kidney and liver disease, alpha 1 beta 1 on mesangial and stellate cells drives collagen deposition, and blocking antibodies have shown benefit in fibrosis and arthritis models. It is also used as an endothelial progenitor marker in regenerative medicine.
-
Integrin alpha 1 beta 1 Recombinant Proteins (2)
-
Inhibitors & Agonists (3)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
