Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His)

Integrin alpha-1/beta-1, a receptor for laminin and collagen, recognizes the proline-hydroxylated sequence G-F-P-G-E-R within collagen. This integral protein negatively regulates EGF-stimulated cell growth and forms a heterodimeric complex with beta-1, interacting with the small GTPase RAB21. Through its cytoplasmic domain, Integrin alpha-1/beta-1 engages with PTPN2, activating phosphatase activity towards EGFR, exerting a negative regulatory influence on EGF signaling, highlighting its multifaceted role in cellular responses. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha A1 beta 1 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Mouse (HEK293, His), has molecular weight of 140-200 kDa (ITGA1) & 100-115 kDa (ITGB1), respectively.

The Integrin alpha-1/beta-1 protein functions as a receptor for both laminin and collagen, recognizing the proline-hydroxylated sequence G-F-P-G-E-R within collagen. Integral to anchorage-dependent processes, it negatively regulates EGF-stimulated cell growth. Forming a heterodimeric complex, Integrin alpha-1 associates with beta-1, and it interacts with the small GTPase RAB21. Moreover, through its cytoplasmic domain, Integrin alpha-1/beta-1 engages with PTPN2, activating the phosphatase activity of PTPN2 towards EGFR and thereby exerting a negative regulatory influence on EGF signaling pathways. These multifaceted interactions underscore Integrin alpha-1/beta-1's role in orchestrating cellular responses to the extracellular matrix and growth factor signaling.

Mouse

HEK293

C-His

Q3V3R4 (F29-P1141)&P09055-1 (Q21-D728)

109700

140-200 kDa (ITGA1) & 100-115 kDa (ITGB1

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.