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Integrin alpha A1 beta 1 Protein, Human (HEK293, His)

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ITGA1 Protein, a cell surface receptor, plays a crucial role in cell adhesion, migration, and tissue development. Dysregulation of ITGA1 Protein has been linked to various diseases, including cancer and fibrosis. Targeting ITGA1 Protein may provide potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting tumor growth, and preventing tissue fibrosis. Integrin alpha A1 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha A1 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Human (HEK293, His), has molecular weight of 160-200 kDa.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

ITGA1 Protein, a cell surface receptor, plays a crucial role in cell adhesion, migration, and tissue development. Dysregulation of ITGA1 Protein has been linked to various diseases, including cancer and fibrosis. Targeting ITGA1 Protein may provide potential therapeutic interventions in these conditions by modulating cell adhesion, inhibiting tumor growth, and preventing tissue fibrosis. Integrin alpha A1 beta 1 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha A1 beta 1 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha A1 beta 1 Protein, Human (HEK293, His), has molecular weight of 160-200 kDa.

Background

The ITGA1 protein, also known as integrin alpha-1/beta-1, functions as a receptor for laminin and collagen. It specifically recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Additionally, ITGA1 is involved in the anchorage-dependent negative regulation of EGF-stimulated cell growth. It forms a heterodimer with a beta subunit, associating with beta-1. ITGA1 also interacts with RAB21 and with PTPN2, activating PTPN2 phosphatase activity towards EGFR and exerting a negative regulation on EGF signaling.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-8*His
  • Accession

    P56199-1 (F29-P1141)&P05556-1 (Q21-D728)

  • Gene ID
    3672&3688
  • Synonyms

    ITGA1; Very Late Antigen-1; Integrin Subunit Alpha 1; Integrin Alpha-1; CD49a; VLA-1; VLA1; Very Late Activation Protein 1; CD49 Antigen-Like Family Member A; Integrin, Alpha 1; Laminin And Collagen Receptor; CD49a Antigen; ITGB1; Very Late Activation Pro

  • Predicted Molecular Mass

    129.1 kDa (ITGA1) & 83.2 kDa (ITGB1)

  • Molecular Weight

    Approximately 180-210 kDa (ITGA1) & 100-130 kDa (ITGB1), based on SDS-PAGE under non reducing (N) conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 7.5, 8% trehalose.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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