91037-65-9
91037-65-9
Chemical Structure
Arg-Gly-Asp-Ser
Synonym(s): RGDS peptide; Fibronectin tetrapeptide
- CAS No.: 91037-65-9
- Formula:C15H27N7O8
- Molecular Weight:433.42
IUPAC Name: (6S,12S,15S)-1,6-diamino-12-(carboxymethyl)-15-(hydroxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid
InChIKey: NNRFRJQMBSBXGO-CIUDSAMLSA-N
SMILES: O=C(N[C@@H](CO)C(O)=O)[C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O
Biological Activity: Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Arg-Gly-Asp-Ser | 98.70% | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. | ||||||||||||||||||||
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Arg-Gly-Asp-Ser (Standard) | ≥98% | Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. | ||||||||||||||||||||
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RGD | 99.60% | RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins. | ||||||||||||||||||||
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Gly-Arg-Gly-Asp-Ser | 99.83% | Gly-Arg-Gly-Asp-Ser (GRGDS) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ～5 and ～6.5 μM | ||||||||||||||||||||
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Arg-Gly-Glu-Ser | Arg-Gly-Glu-Ser is a polypeptide related to RGD and is a negative control for Arg-Gly-Asp-Ser (HY-12290). | |||||||||||||||||||||
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Arg-Gly-Asp-Cys | Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding. | |||||||||||||||||||||
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CRGDS | CRGDS is a cell-adhesive peptide targeting αvβ3 integrin. CRGDS competitively interferes with RGD-matrix protein adhesion and mediates integrin-dependent tumor cell uptake. CRGDS modulates endothelial viability, proliferation, capillary-like formation, and VEGF receptor inhibitory responses, whereas excessive presentation disrupts VEGF receptor-integrin synergy. CRGDS can be used in vascular disease and tumor research. | |||||||||||||||||||||
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Ac-RGDS-NH2 | Ac-RGDS-NH2, a tetrapeptide, is an integrin antagonist. Ac-RGDS-NH2 competitively binds to the GPIIb/IIIa receptor (Ki = 4.2 μM), inhibiting the binding of fibrinogen to platelets and thereby effectively suppressing platelet aggregation. Ac-RGDS-NH2 can be used for research on thrombosis. | |||||||||||||||||||||
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RGDV | RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect. | |||||||||||||||||||||
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SDGR | SDGR is a Ser-Asp-Gly-Arg tetrapeptide sequence that effectively inhibits fibronectin-mediated cell attachment | |||||||||||||||||||||
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RGDT | RGDT is a synthetic peptide. RGDT can be used in the research of cancer. | |||||||||||||||||||||
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KGDS | 99.78% | KGDS is synthetic peptides, targeting integrin GPIIb-IIIa located on the membrane of human activated platelets. Amino acid sequence: Lys-Gly-Asp-Ser. | ||||||||||||||||||||
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