CRGDS
CRGDS is a cell-adhesive peptide targeting αvβ3 integrin. CRGDS competitively interferes with RGD-matrix protein adhesion and mediates integrin-dependent tumor cell uptake. CRGDS modulates endothelial viability, proliferation, capillary-like formation, and VEGF receptor inhibitory responses, whereas excessive presentation disrupts VEGF receptor-integrin synergy. CRGDS can be used in vascular disease and tumor research.
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- CAS. Nr.: 726187-79-7
- Formel: C18H32N8O9S
- Molecular Weight:536.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
Beschreibung
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αvβ3 |
VEGF |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hMSC
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Concentration:5 mM; 25 mM
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Incubation Time:24 h (attachment); 96 h (proliferation); 10 min (UV conjugation)
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Result:At 5 and 25 mM, cell attachment and proliferation were supported from day 1 to day 4.
The 25 mM functionalized grafts showed more hMSC attachment and proliferation than 5 mM functionalized grafts at both time points; 25 mM was selected for subsequent studies.
On day 4, the highest cell density among compared groups was on functionalized coaxial grafts; CCK absorbance was higher on functionalized coaxial grafts than on PCL grafts.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (8-9 months old, ~400 g)[1]
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Dosage:5 or 25 mM (CRGDS); 25 mM plus 50 nM TGF-β1 (CRGDS/TGF-β1)
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Administration:local graft conjugation (submersion 30 min, UV 15 min); implantation for 7 days
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Result:In acellular grafts, cell density at explantation was higher than in PCL grafts, and endothelial vWF+ lining and α-SMA+ cells were present; PCL grafts showed sparse endothelial and smooth muscle cell populations.
The α-SMA+ smooth muscle layer was thicker than in PCL grafts, and graft wall thickness was greater than in PCL grafts.
ECM production was higher than in PCL grafts, with increased collagen and elastin deposition.
In grafts with TGF-β1, the α-SMA+ smooth muscle layer was thicker than in grafts without TGF-β1; the thickest smooth muscle layer was in grafts with TGF-β1 preseeded with rMSCs.
Grafts with TGF-β1 also showed increased collagen and elastin deposition versus PCL grafts, while ECM production tended to be lower than in grafts without TGF-β1.
Chemical Information
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CAS. Nr. 726187-79-7
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Molecular Weight 536.56
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Formel C18H32N8O9S
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Sequence
Cys-Arg-Gly-Asp-Ser
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Sequence Shortening
CRGDS
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[2]. Mendes AX, et al. Alginate-methacrylate-RGD microspheres (Alg-MR-MS) for cell expansion and delivery in tissue engineering. Biomedical materials (Bristol, England). 2026 Oct 20;21(5). [Content Brief]
[4]. Wang X, et al. Active tumor-targeting luminescent gold clusters with efficient urinary excretion. Chemical communications (Cambridge, England). 2016 Jul 28;52(59):9232-5. [Content Brief]
[5]. Nguyen EH, et al. Differential effects of cell adhesion, modulus and VEGFR-2 inhibition on capillary network formation in synthetic hydrogel arrays. Biomaterials. 2014 Feb;35(7):2149-61. [Content Brief]
[6]. Khang A, et al. Quantifying heart valve interstitial cell contractile state using highly tunable poly(ethylene glycol) hydrogels. Acta biomaterialia. 2019 Sep 15;96:354-367. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CRGDS Related Classifications
HY-P11172 Related Classifications
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Keywords
- CRGDS
- 726187-79-7
- Biochemical Assay Reagents
- Integrin
- VEGFR
- RGD-matrix protein adhesion
- VEGF receptor
- angiogenesis
- arterial regeneration
- endothelial capillary-like formation
- integrin-dependent tumor cell uptake
- mesenchymal stem cell adhesion
- vascular smooth muscle differentiation
- α-SMA
- αvβ3 integrin
- Inhibitor
- inhibitor
- inhibit