Integrin alpha V beta 8
Integrin alpha V beta 8 pairs CD51 with the beta-8 subunit and, like alpha V beta 6, activates latent TGF-beta-1 through its RGD motif. Distinctively, the beta-8 cytoplasmic tail couples poorly to the cytoskeleton, so TGF-beta release occurs in a protease-dependent manner rather than by mechanical force. The receptor is expressed on dendritic cells, regulatory T cells, astrocytes and keratinocytes, where it shapes immune tolerance and central nervous system homeostasis. By controlling local TGF-beta availability, alpha V beta 8 restrains anti-tumor immunity, and blocking antibodies are in clinical trials to combine with checkpoint inhibitors in immuno-oncology.
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Integrin alpha V beta 8 Recombinant Proteins (8)
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Inhibitors & Agonists (12)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
