Integrin alpha V beta 8 Protein, Mouse (HEK293, His)

Integrin alpha V beta 3 (ITGAV:ITGB3) functions as a receptor for CD40LG, enhancing Lilrb4a inhibitory effects on mast cell activation. It suppresses marginal zone B cell antibody production through Lilrb4a interaction. ITGAV:ITGB3, forming a heterodimer with ITGAV, interacts with ligands such as RAB25, CIB1, FBLN5, and more. It also forms a complex with PTPRZ1 and PTN, stimulating endothelial cell migration. Integrin alpha V beta 8 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha V beta 8 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha V beta 8 Protein, Mouse (HEK293, His), has molecular weight of 80-140 kDa.

Integrin alpha-V/beta-3 (ITGAV:ITGB3) acts as a receptor for CD40LG and binds to the Lilrb4a/Gp49b receptor, enhancing its inhibitory effect on mast cell activation. ITGAV:ITGB3 also suppresses marginal zone B cell antibody production through interaction with Lilrb4a. It forms a heterodimer with ITGAV and interacts with various ligands, including RAB25, CIB1, FBLN5, CCN3, ADGRA2, FGF2, CX3CR1, CX3CL1, NRG1, ERBB3, FGF1, FGFR1, IGF1, IGF1R, IGF2, and PTN. It also forms a complex with PTPRZ1 and PTN to stimulate endothelial cell migration.

Immobilized Mouse ITGAV&ITGB8, His Tag at 5 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC₅₀ of ≤3 μg/mL determined by ELISA.

Mouse

HEK293

C-8*His

P43406 (F31-V988)&Q0VBD0 (G22-S679)

16410&320910

Approximately 80-140 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.