Integrin Ligand

Integrin Ligands (27):

Cat. No.	Product Name	Effect	Purity

HY-P11339A

c-RGD-SH TFA	Ligand	98.84%
c-RGD-SH TFA is an Integrin αvβ3 ligand. c-RGD-SH TFA conjugated with core-crosslinked polymeric micelles (CCPM) can be used for synthesis a dual modality nanoparticle probe, and this probe labeled with both Cy7 and ¹¹¹In can be used for SPECT and NIRF imaging of tumor.

HY-P990764

Sigvotatug	Ligand	99.67%
Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957).

HY-P11328

GFOGER peptide	Ligand	99.53%
GFOGER peptide is an artificially synthesized collagen-mimetic sequence. GFOGER peptide acts as a ligand for α2β1, α11β1 and α1β1 integrins, thereby supporting integrin-mediated cell adhesion to collagen. GFOGER peptide triggers signaling pathways mediated by the α2β1 integrin receptor and upregulates osteoblast differentiation. GFOGER peptide accelerates and enhances bone formation at sites of refractory femoral defects. GFOGER peptide can be passively adsorbed onto polymer scaffolds for cell-free/growth factor-free bone formation. GFOGER peptide is used in biomaterials such as hydrogels and 3D bioinks for tissue engineering research including bone formation.

HY-NP175

Collagen (bovine skin)	Ligand
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development.

HY-P5098

E(c(RGDfK))2	Ligand	99.82%
E (c (RGDfK)) 2 is a αvβ3 integrin ligand and tumor-targeting agent. E (c (RGDfK)) 2 binds to αvβ3 integrin, mediates receptor-mediated endocytosis of conjugated payloads, and inhibits integrin-dependent cell adhesion to fibrinogen. E (c (RGDfK)) 2 inhibits the proliferation of cancer cells and endothelial cells. E (c (RGDfK)) 2 preferentially accumulates in orthotopic mouse breast tumors and human ovarian cancer xenograft tumors. E (c (RGDfK)) 2 can be used in research related to glioblastoma, lung cancer, breast adenocarcinoma and ovarian cancer.

HY-P990764B

Sigvotatug (Biotinylated)	Ligand	≥99.0%
Sigvotatug (Biotinylated) is a biotinylated derivative of Sigvotatug (HY-P990764). Sigvotatug (Biotinylated) is a humanized IgG1 κ monoclonal antibody inhibitor against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P1897A

Fibronectin sctive fragment control acetate	Ligand	99.19%
Fibronectin active fragment control acetate is an active peptide fragment of fibronectin. Fibronectin is a glycoprotein interacting with integrins. Fibronectin active fragment control acetate can be used as a control for Gly-Arg-Gly-Asp-Ser (HY-P0295).

HY-177580

GP1 precursor	Ligand
GP1 precursor has high affinity to GPIIb/IIIa receptors of activated platelets. GP1 precursor can be radiolabeled with [¹⁸F] and used as a PET Tracer for visualizing active platelet aggregation at the molecular level. GP1 precursor can be used for the detection of Thrombi.

HY-P11708

Relitegatide	Ligand
Relitegatide is a cyclic peptide with selectivity for the αvβ6 integrin. Relitegatide can be used for the synthesis of Relitegatide brexetan (HY-P11276).

HY-176300

RGD-DA6	Ligand
RGD-DA6 is an αvβ3-targeted ligand. RGD-DA6 consists of RGDfK (an integrin αvβ3-targeted RGD peptide), DOTADG, d-Glu, Lys, AMBA, and IPBA. RGD-DA6 can be radiolabeled as an αvβ3-targeted radioligand and used for high-contrast tumor imaging and enhanced anticancer efficacy.

HY-185469

Tris-ανβ6 integrin ligand-3	Ligand
Tris-ανβ6 integrin ligand-3 (the ligand part of Compound 203) is a Tris-ανβ6 integrin ligand.

HY-P11780

KAFDITYVRLKF	Ligand
KAFDITYVRLKF is a selective, competitive integrin α_vβ₃ binder. KAFDITYVRLKF induces the production of MMP-9. KAFDITYVRLKF blocks monocyte migration, promotes melanoma cell migration, protects neurons, and improves motor and cognitive functions. KAFDITYVRLKF can be used in research related to melanoma and Parkinson's disease.

HY-P3530

G-{d-Arg}-GDSP	Ligand
G-{d-Arg}-GDSP is an RGD peptide analogue that binds to the adhesion receptor of integrins and inhibits cellular fibronectin attachment as well as osteoclast resorption.

HY-185468

Tris-ανβ6 integrin ligand-2	Ligand
Tris-ανβ6 integrin ligand-2 (the ligand part of Compound 151) is a Tris-ανβ6 integrin ligand.

HY-P2153

Maraciclatide	Ligand
Maraciclatide is a synthetic molecule that binds with high affinity to α_vβ₃ and α_vβ₅ integrins via the RGD peptide. Maraciclatide can be used to detect bone metastasis, breast tumors, vascular disease and rheumatoid arthritis in animal models. Maraciclatide can be studied in research on angiogenesis and inflammation.

HY-185466

ανβ6 Integrin ligand-2	Ligand
ανβ6 Integrin ligand-2 is a ανβ6 integrin ligand.

HY-D2062

ATTO 740 NHS ester	Ligand
ATTO 740 NHS ester is a near-infrared fluorescent dye and a multimodal fluorescence/photoacoustic contrast agent with excellent near-infrared emission properties and extremely high photostability. The photoacoustic signal of ATTO 740 NHS ester shows no significant decrease after continuous irradiation with a 750 nm laser for 30 min, making it suitable for in vivo fluorescence imaging and photoacoustic contrast imaging. When conjugated with the cystine knot peptide R01, ATTO 740 NHS ester enables precise detection of integrin αvβ6-positive cells and tumors in nude mouse xenograft models.

HY-P1654A

A20FMDV2-Cys	Ligand
A20FMDV2-Cys is a cysteine-containing 20-mer peptide that targets integrin αvβ6 with high affinity. A20FMDV2-Cys can be used for targeted liposome modification to enhance liver and bile duct targeting. A20FMDV2-Cys is applicable for research in drug delivery.

HY-185467

Tris-ανβ6 integrin ligand-1	Ligand
Tris-ανβ6 integrin ligand-1 (the ligand part of Compound 150) is a Tris-ανβ6 integrin ligand.

HY-P11773

3P-RGD2	Ligand
3P-RGD2 is a dimeric cyclic RGD (Arg-Gly-Asp) peptide. When radiolabeled with ^99mTc, 3P-RGD2 serves as a selective radiotracer for integrin α_vβ₃. When radiolabeled with ^99mTc, 3P-RGD2 enables single-photon emission computed tomography imaging of integrin α_vβ₃.

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