2. Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Integrin ADC Antibody
  4. Sigvotatug

Sigvotatug  (Synonyms: SGN-B6A antibody)

Cat. No.: HY-P990764 Purity: 99.67%
COA
SDS
Technical Support

Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957).

For research use only. We do not sell to patients.

CAS No. : 2764774-90-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Sigvotatug:

Sigvotatug Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

Sigvotatug vedotin (SGN-B6A) is an ADC molecule with anti-tumor activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sigvotatug Related Antibodies
Clinical Trial
Gene ID

3694  [NCBI]

Accession

P18564
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

144.48 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa
Biological Activity
  • Immobilized Sigvotatug can bind Human Integrin alpha V beta 6 (ITGAV&ITGB6). The EC50 for this effect is 99.20 ng/mL.
  • Flow Cytometry analysis of HT-29 cells labelling ITGB6 (red) with Sigvotatug (anti-ITGB6) (HY-P990764). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).
Purity & Documentation

Purity: 99.67%

SDS (251 KB)

COA (232 KB) SDS-PAGE (84 KB) SEC-HPLC (127 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Sigvotatug Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sigvotatug2764774-90-3SGN-B6A antibodyIntegrinADC AntibodySGN-B6AantibodyADC antibodyInhibitorinhibitorinhibit

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