ITGB6 - integrin subunit beta 6 Gene

Also Known as AI1H

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3694

About ITGB6

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:160,099,671-160,200,272 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues, 8 paralogues and is associated with 4 phenotypes. Biased expression in lung (RPKM 25.8), urinary bladder (RPKM 17.2) and 12 other tissues.

Summary

This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ITGB6 Products (7)

mRNA	Protein	Name
NM_000888.5	NP_000879.2	integrin beta-6 isoform a precursor
NM_001282353.2	NP_001269282.1	integrin beta-6 isoform a precursor
NM_001282354.2	NP_001269283.1	integrin beta-6 isoform b precursor
NM_001282355.2	NP_001269284.1	integrin beta-6 isoform c precursor
NM_001282388.2	NP_001269317.1	integrin beta-6 isoform d
NM_001282389.2	NP_001269318.1	integrin beta-6 isoform e
NM_001282390.2	NP_001269319.1	integrin beta-6 isoform f

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17158881	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	17158881	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	17158881	GOA
part of integrin alphav-beta6 complex	IDA IDA: Inferred from direct assay	22278742	GOA
part of integrin alphav-beta6 complex	IPI IPI: Inferred from physical interaction	25383667	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB6 Protein Structure

Integrin_beta

EGF_2

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
788 a.a.

Protein Preferred Names	Protein Names
integrin beta-6	integrin, beta 6

Recombinant ITGB6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73867	Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His)	P06756-1 (F31-V992)&P18564-1 (G22-N707)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77721	Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi)	P06756-1 (F31-V992)&P18564-1 (G22-N707)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700768	ITGB6 Protein, Human (HEK293, His)	P18564-1 (G22-N707)	≥ 95%, as determined by Bis-Tris PAGE.

ITGB6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83377	Integrin beta 6 Antibody (YA3122)	WB, IP	Human, Mouse, Rat
HY-P83377A	Integrin beta 6 Antibody (YA3122)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P86456	Integrin beta 6 Antibody (YA6148)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Amelogenesis Imperfecta, Type Ih	AI1H Amelogenesis Imperfecta Type 1h Amelogenesis Imperfecta Type Ih Amelogenesis Imperfecta 1h Amelogenesis Imperfecta, Type 1h
Alopecia-Mental Retardation Syndrome 1	APMR1 Alopecia-Intellectual Disability Syndrome 1 Amr Syndrome Alopecia-Intellectual Disability Syndrome Amr Syndrome 1 Alopecia With Severe Intellectual Deficit Apmr Alopecia Intellectual Disbility Syndrome 1 Perniola-Krajewska-Carnevale Syndrome Alopecia - Intellectual Disability Syndrome Alopecia With Mental Retardation Syndrome 1 Perniola Krajewska Carnevale Syndrome
Amelogenesis Imperfecta, Type Iiia	Ai3 Adhcai Amelogenesis Imperfecta Type 3 AI3A Amelogenesis Imperfecta, Type Iii Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant Amelogenesis Imperfecta Type 3a Amelogenesis Imperfecta Hypomineralization Type Amelogenesis Imperfecta Type Iii Hypocalcified Amelogenesis Imperfecta Amelogenesis Imperfecta, Type 3 Amelogenesis Imperfecta, Hypomineralization Type Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3a Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant
Hypoplastic Amelogenesis Imperfecta	Amelogenesis Imperfecta Type 1 Amelogenesis Imperfecta, Hypoplastic Type Amelogenesis Imperfecta Local Hypoplastic Form
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Mouth Disease	Mouth Diseases Mouth Disorders
Pulmonary Emphysema
Premature Ovarian Failure 19	POF19 Primary Ovarian Insufficiency 19 Poi19 Ovarian Failure, Premature, Type 19
Bullous Keratopathy	Bk - [Bullous Keratopathy]
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Cholangiolocellular Carcinoma
Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia	Junctional Epidermolysis Bullosa With Pyloric Atresia Carmi Syndrome Epidermolysis Bullosa, Junctional, With Pyloric Atresia Jeb-Pa JEB5B Epidermolysis Bullosa Junctionalis With Pyloric Atresia Aplasia Cutis Congenita With Gastrointestinal Atresia Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita Eb-Pa-Acc Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome Jeb With Pyloric Atresia Epidermolysis Bullosa Letalis, With Pyloric Atresia Pa-Jeb Epidermolysis Bullosa With Pyloric Atresia
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-164957	Sigvotatug vedotin	Inhibitor	99.68%	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990764	Sigvotatug	Ligand	99.67%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06970	ITGB6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18525	Itgb6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25007	Itgb6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990667B	STX-100 (Biotinylated)	Inhibitor	≥99.0%	Unkown
HY-P990764B	Sigvotatug (Biotinylated)	Ligand	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ITGB6	RGD	RGD:1303119
Bos taurus	ITGB6	VGNC	VGNC:30331
Felis catus	ITGB6	VGNC	VGNC:67855
Macaca mulatta	ITGB6	VGNC	VGNC:73789
Canis familiaris	ITGB6	VGNC	VGNC:42141
Mus musculus	ITGB6	MGD	MGI:96615
Others	ITGB6	NCBI