ITGB6 - integrin subunit beta 6 Gene

Homo sapiens

Also known as AI1H

Gene ID: 3694 | Gene type: protein coding

About ITGB6

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:160,099,671-160,200,272 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues, 8 paralogues and is associated with 4 phenotypes. Biased expression in lung (RPKM 25.8), urinary bladder (RPKM 17.2) and 12 other tissues.

Summary

This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ITGB6 Products(7)

mRNA	Protein	Name
NM_000888.5	NP_000879.2	integrin beta-6 isoform a precursor
NM_001282353.2	NP_001269282.1	integrin beta-6 isoform a precursor
NM_001282354.2	NP_001269283.1	integrin beta-6 isoform b precursor
NM_001282355.2	NP_001269284.1	integrin beta-6 isoform c precursor
NM_001282388.2	NP_001269317.1	integrin beta-6 isoform d
NM_001282389.2	NP_001269318.1	integrin beta-6 isoform e
NM_001282390.2	NP_001269319.1	integrin beta-6 isoform f

ITGB6 Protein Structure

Integrin_beta

EGF_2

Integrin_B_tail

Integrin_b_cyt

0
200
400
600
788 a.a.

Protein Preferred Names

Protein Names

integrin beta-6

integrin, beta 6

Recombinant ITGB6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73867	Integrin alpha V beta 6 Protein, Human (HEK293, Flag-His)	P06756 (F31-V992)&P18564 (G22-N707)	≥95%
HY-P77721	Integrin alpha V beta 6 Protein, Human (HEK293, His-Avi)	P06756 (F31-V992)&P18564 (G22-N707)	≥95%
HY-P700768	ITGB6 Protein, Human (HEK293, His)	P18564-1 (G22-N707)	≥95%

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Type Ih

AI1H	Amelogenesis Imperfecta Type 1h
Amelogenesis Imperfecta Type Ih	Amelogenesis Imperfecta 1h
Amelogenesis Imperfecta, Type 1h

Alopecia-Mental Retardation Syndrome 1

APMR1	Alopecia-Intellectual Disability Syndrome 1
Amr Syndrome	Alopecia-Intellectual Disability Syndrome
Amr Syndrome 1	Alopecia With Severe Intellectual Deficit
Apmr	Alopecia Intellectual Disbility Syndrome 1
Perniola-Krajewska-Carnevale Syndrome	Alopecia - Intellectual Disability Syndrome
Alopecia With Mental Retardation Syndrome 1	Perniola Krajewska Carnevale Syndrome

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Hypoplastic Amelogenesis Imperfecta

Amelogenesis Imperfecta Type 1	Amelogenesis Imperfecta, Hypoplastic Type
Amelogenesis Imperfecta Local Hypoplastic Form

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Mouth Disease

Mouth Diseases

Mouth Disorders

Pulmonary Emphysema

Premature Ovarian Failure 19

POF19	Primary Ovarian Insufficiency 19
Poi19	Ovarian Failure, Premature, Type 19

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Cholangiolocellular Carcinoma

Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia

Junctional Epidermolysis Bullosa With Pyloric Atresia	Carmi Syndrome
Epidermolysis Bullosa, Junctional, With Pyloric Atresia	Jeb-Pa
JEB5B	Epidermolysis Bullosa Junctionalis With Pyloric Atresia
Aplasia Cutis Congenita With Gastrointestinal Atresia	Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita
Eb-Pa-Acc	Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome
Jeb With Pyloric Atresia	Epidermolysis Bullosa Letalis, With Pyloric Atresia
Pa-Jeb	Epidermolysis Bullosa With Pyloric Atresia

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06970	ITGB6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ITGB6	RGD	RGD:1303119
Bos taurus	ITGB6	VGNC	VGNC:30331
Felis catus	ITGB6	VGNC	VGNC:67855
Macaca mulatta	ITGB6	VGNC	VGNC:73789
Canis familiaris	ITGB6	VGNC	VGNC:42141
Mus musculus	ITGB6	MGD	MGI:96615
Others	ITGB6	NCBI

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