Integrin beta 6 Antibody (YA3122)(PBS only)

Art. -Nr.: HY-P83377A: Data Sheet User Guide for Antibodies
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Integrin beta 6 Antibody (YA3122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin beta 6.

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100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

Integrin beta 6 Antibody (YA3122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin beta 6.

Host

Rabbit

Molekulargewicht

Predicted band size: 86 kDa;

Observed band size: 86 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P18564

Gene ID

3694 [NCBI]

Immunogen

A synthetic peptide of human ITGB6

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IP IP: Immunoprecipitation	1:20

Reinheit	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17158881, PubMed:17545607). It recognizes the sequence R-G-D in its ligands (PubMed:17158881, PubMed:17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17158881, PubMed:17545607). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447); (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260)

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell junction, focal adhesion

Isoforms & Post-Translational Modification：P18564 has 2 isomers: P18564-1: 85936 Da (predicted); P18564-2: 74958 Da (predicted).

Subunit：Heterodimer of an alpha and a beta subunit (PubMed:11807098, PubMed:17158881, PubMed:17545607). Interacts with FLNB (PubMed:11807098). Interacts with HAX1 (PubMed:17545607). ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881). ITGAV:ITGB6 interacts with TGFB1 (PubMed:22278742, PubMed:28117447)

Research Field

Signal Transduction

Synonyms

AI1H; Integrin beta-6

Dokumentation

User Guide for Antibodies (1077 KB)