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Integrin beta 6 Antibody (YA3122)(PBS only)

(Synonyms: AI1H; Integrin beta-6)

Integrin beta 6 Antibody (YA3122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin beta 6.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • Integrin beta 6 Antibody (YA3122)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:20

Product Details

Description

Integrin beta 6 Antibody (YA3122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin beta 6.

  • Host Rabbit
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 86 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 86 kDa
Immunogen

A synthetic peptide of human ITGB6

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Integrin beta 6 is an Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1[1][2][3][4][5][6].

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein; Cell junction, focal adhesion

  • Isoforms & Post-Translational Modification

    P18564 has 2 isomers: P18564-1: 85936 Da (predicted); P18564-2: 74958 Da (predicted).

  • Subunit

    Heterodimer of an alpha and a beta subunit (PubMed:11807098, PubMed:17158881, PubMed:17545607). Interacts with FLNB (PubMed:11807098). Interacts with HAX1 (PubMed:17545607). ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881). ITGAV:ITGB6 interacts with TGFB1 (PubMed:22278742, PubMed:28117447)

  • SwissProt ID

    P18564

  • Gene ID
    3694 [NCBI]
  • Synonyms

    AI1H; Integrin beta-6

  • Research Field

    Signal Transduction

Integrin beta 6 Antibody (YA3122)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Integrin beta 6 Antibody (YA3122)(PBS only) Product Image