ATTO 740 NHS ester
ATTO 740 NHS ester is a near-infrared fluorescent dye and a multimodal fluorescence/photoacoustic contrast agent with excellent near-infrared emission properties and extremely high photostability. The photoacoustic signal of ATTO 740 NHS ester shows no significant decrease after continuous irradiation with a 750 nm laser for 30 min, making it suitable for in vivo fluorescence imaging and photoacoustic contrast imaging. When conjugated with the cystine knot peptide R01, ATTO 740 NHS ester enables precise detection of integrin αvβ6-positive cells and tumors in nude mouse xenograft models.
For research use only. We do not sell to patients.
- CAS No.: 1448146-89-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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αvβ6 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:nude mice model (8-week-old female, Charles River)[1]
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Dosage:200 μL of 6×10-5 M A740-R01
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Administration:i.v.; single dose
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Result:Produced a 2-fold photoacoustic signal increase (1.87 arbitrary units vs. baseline 0.99 arbitrary units) in integrin αvβ6-positive A431 xenografts 1 h after injection.
Produced an 8-fold fluorescence signal increase (8.27 arbitrary units vs. baseline 1.01 arbitrary units) in integrin αvβ6-positive A431 xenografts 1 h after injection.
Showed no significant photoacoustic signal changes (pre-injection: 0.96 arbitrary units; 1 h post-injection: 1.07 arbitrary units) in integrin αvβ6-negative 293T xenografts.
Showed no significant fluorescence signal changes (pre-injection: 1.00 arbitrary units; 1 h post-injection: 1.10 arbitrary units) in integrin αvβ6-negative 293T xenografts.
Exhibited the highest maximum radiance in the liver, followed by the intestines, spleen, and kidneys in ex vivo fluorescence imaging 1 h after injection.
Detected increased photoacoustic signal in the liver at 1 h after injection, temporally dependent increases in intestinal signals peaking at 4 h, and minimal renal contrast throughout the study.
Chemical Information
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CAS No. 1448146-89-1
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SMILES
[ATTO 740 NHS ester]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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