245120-10-9
Chemical Structure
GFOGER peptide
- CAS No.: 245120-10-9
- Formula:C29H43N9O10
- Molecular Weight:677.71
IUPAC Name: (2S,5S,11S,14S)-17-amino-11-(3-aminopropyl)-14-benzyl-5-(2-carboxyethyl)-2-(3-guanidinopropyl)-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaheptadecanoic acid
InChIKey: RCKPSNHJCRFAEG-SYAJIYQZSA-N
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](C[C@H](C2)O)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)CN
Biological Activity: GFOGER peptide is an artificially synthesized collagen-mimetic sequence. GFOGER peptide acts as a ligand for α2β1, α11β1 and α1β1 integrins, thereby supporting integrin-mediated cell adhesion to collagen. GFOGER peptide triggers signaling pathways mediated by the α2β1 integrin receptor and upregulates osteoblast differentiation. GFOGER peptide accelerates and enhances bone formation at sites of refractory femoral defects. GFOGER peptide can be passively adsorbed onto polymer scaffolds for cell-free/growth factor-free bone formation. GFOGER peptide is used in biomaterials such as hydrogels and 3D bioinks for tissue engineering research including bone formation[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GFOGER peptide | 99.53% | GFOGER peptide is an artificially synthesized collagen-mimetic sequence. GFOGER peptide acts as a ligand for α2β1, α11β1 and α1β1 integrins, thereby supporting integrin-mediated cell adhesion to collagen. GFOGER peptide triggers signaling pathways mediated by the α2β1 integrin receptor and upregulates osteoblast differentiation. GFOGER peptide accelerates and enhances bone formation at sites of refractory femoral defects. GFOGER peptide can be passively adsorbed onto polymer scaffolds for cell-free/growth factor-free bone formation. GFOGER peptide is used in biomaterials such as hydrogels and 3D bioinks for tissue engineering research including bone formation. | ||||||||||||||||||||
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- [1]. Wojtowicz AM, et al. Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials. 2010;31(9):2574-2582. [Content Brief]
- [2]. Zhang WM, et al. alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens. J Biol Chem. 2003 Feb 28;278(9):7270-7. [Content Brief]
- [3]. Mansour A, et al. GFOGER Peptide Modifies the Protein Content of Extracellular Vesicles and Inhibits Vascular Calcification. Front Cell Dev Biol. 2020;8:589761. Published 2020 Nov 30. [Content Brief]
Keywords
