E(c(RGDfK))2
Based on 1 Customer Validation
E (c (RGDfK)) 2 is a αvβ3 integrin ligand and tumor-targeting agent. E (c (RGDfK)) 2 binds to αvβ3 integrin, mediates receptor-mediated endocytosis of conjugated payloads, and inhibits integrin-dependent cell adhesion to fibrinogen. E (c (RGDfK)) 2 inhibits the proliferation of cancer cells and endothelial cells. E (c (RGDfK)) 2 preferentially accumulates in orthotopic mouse breast tumors and human ovarian cancer xenograft tumors. E (c (RGDfK)) 2 can be used in research related to glioblastoma, lung cancer, breast adenocarcinoma and ovarian cancer.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 250612-47-6
- Formula: C59H87N19O16
- Molecular Weight:1318.44
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
E(c(RGDfK))2 (72 hr) weakly inhibits the viability of U87-MG human glioblastoma cells and human umbilical vein endothelial cells, with IC50 values of 2500 nM and 400 nM, respectively[1].
E(c(RGDfK))2 (50 μM; 30 min pre-incubation) reduces the adhesion of human umbilical vein endothelial cells to fibrinogen by approximately 35%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
E(c(RGDfK))2 (54.5 mg/kg; i.v.; 3 total doses on days 10, 17, 24) shows minimal antitumor efficacy against OVCAR-3 xenografts, with an optimum T/C of 80% at day 27[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 250612-47-6
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Appearance Solid
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Molecular Weight 1318.44
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Formula C59H87N19O16
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Color White to off-white
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Sequence
Glu[cyclo(Arg-Gly-Asp-{d-Phe}-Lys)]-cyclo(Arg-Gly-Asp-{d-Phe}-Lys)
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Sequence Shortening
E[cyclo(RGD-{d-Phe}-K)]-cyclo(RGD-{d-Phe}-K)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (75.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7585 mL | 3.7924 mL | 7.5847 mL | 18.9618 mL |
| 5 mM | 0.1517 mL | 0.7585 mL | 1.5169 mL | 3.7924 mL | |
| 10 mM | 0.0758 mL | 0.3792 mL | 0.7585 mL | 1.8962 mL | |
| 15 mM | 0.0506 mL | 0.2528 mL | 0.5056 mL | 1.2641 mL | |
| 20 mM | 0.0379 mL | 0.1896 mL | 0.3792 mL | 0.9481 mL | |
| 25 mM | 0.0303 mL | 0.1517 mL | 0.3034 mL | 0.7585 mL | |
| 30 mM | 0.0253 mL | 0.1264 mL | 0.2528 mL | 0.6321 mL | |
| 40 mM | 0.0190 mL | 0.0948 mL | 0.1896 mL | 0.4740 mL | |
| 50 mM | 0.0152 mL | 0.0758 mL | 0.1517 mL | 0.3792 mL | |
| 60 mM | 0.0126 mL | 0.0632 mL | 0.1264 mL | 0.3160 mL |
E(c(RGDfK))2 Related Classifications
HY-P5098 Related Classifications
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