(S,R,S)-AHPC TFA
Based on 3 publication(s) in Google Scholar
(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
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- CAS No.: 1631137-51-3
- Formula: C24H31F3N4O5S
- Molecular Weight:544.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC TFA
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Biological Activity
Description
IC50 & Target
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VHL |
Chemical Information
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CAS No. 1631137-51-3
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Molecular Weight 544.59
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Formula C24H31F3N4O5S
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SMILES
FC(F)(F)C(O)=O.O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2
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Synonyms
VH032-NH2 TFA; VHL ligand 1 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer. [Abstract]2026 May 19;7(5):102763. PMID: 42030934 -
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Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S,R,S)-AHPC TFA Related Classifications
HY-110402 Related Classifications
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