(S,R,S)-AHPC TFA
Based on 2 publication(s) in Google Scholar
(S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
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- CAS No.: 1631137-51-3
- Formula: C24H31F3N4O5S
- Molecular Weight:544.59
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC TFA
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Biological Activity
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VHL |
Chemical Information
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CAS No. 1631137-51-3
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Molecular Weight 544.59
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Formula C24H31F3N4O5S
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SMILES
FC(F)(F)C(O)=O.O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2
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Synonyms
VH032-NH2 TFA; VHL ligand 1 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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