1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC (TFA)

(S,R,S)-AHPC (TFA) (Synonyms: VHL ligand 1 (TFA))

Cat. No.: HY-110402
Handling Instructions

(S,R,S)-AHPC TFA (VHL ligand 1 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA (VHL ligand 1 TFA) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

For research use only. We do not sell to patients.

(S,R,S)-AHPC (TFA) Chemical Structure

(S,R,S)-AHPC (TFA) Chemical Structure

CAS No. : 1631137-51-3

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Description

(S,R,S)-AHPC TFA (VHL ligand 1 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA (VHL ligand 1 TFA) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC50 & Target

VHL

 

Molecular Weight

544.59

Formula

C₂₄H₃₁F₃N₄O₅S

CAS No.

1631137-51-3

SMILES

FC(F)(F)C(O)=O.O=C([[email protected]](C[[email protected]@H](O)C1)N1C([[email protected]@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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(S,R,S)-AHPC (TFA)
Cat. No.:
HY-110402
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