2. PROTAC
  3. Ligands for E3 Ligase
  4. (S,R,S)-AHPC dihydrochloride

(S,R,S)-AHPC dihydrochloride  (Synonyms: VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride)

Cat. No.: HY-101763B
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(S,R,S)-AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC dihydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.

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(S,R,S)-AHPC dihydrochloride Chemical Structure

(S,R,S)-AHPC dihydrochloride Chemical Structure

CAS No. : 2137142-47-1

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(S,R,S)-AHPC dihydrochloride Related Antibodies

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Description

(S,R,S)-AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC dihydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].

IC50 & Target[1]

VHL

 

Molecular Weight

503.49

Formula

C22H32Cl2N4O3S
CAS No.
SMILES

O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S,R,S)-AHPC dihydrochloride Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC2137142-47-1VH032-NH2VHL ligand 1VHL ligand1VHL ligand-1Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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